The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might lead to an increase in methadone plasma concentrations, which could lead to probably fatal respiratory despair. Furthermore, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also end in an increase in methad… Read More